| Citation: |
GAO Jiawei, DENG Xinkai, HAN Xiaobo, LI Xiao, CHAI Yahao, ZHANG Lei. Correlation of Inflammasomes with Pyroptosis and Effect on Coagulation Function[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(6): 1395-1400. DOI: 10.12290/xhyxzz.2024-0012
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Disseminated intravascular coagulation (DIC) triggered by sepsis is a major challenge in the emergency and critical care of severely ill patients. The inflammasome is an essential component of the human immune system, and its activation can mediate pyroptosis and then release interleukin (IL)-1β and IL-18, which further activates platelets and the coagulation system and exacerbates inflammatory responses and coagulation processes, thus creating great uncertainty for the treatment and prognosis of sepsis. This article aims to review the correlation between the inflammasome and pyroptosis, as well as their impact on coagulation function, in hope of providing new insights for the clinical treatment of DIC.
| [1] |
Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta[J]. Mol Cell, 2002, 10(2): 417-426. DOI: 10.1016/S1097-2765(02)00599-3
|
| [2] |
Sharma M, de Alba E. Structure, activation and regulation of NLRP3 and AIM2 inflammasomes[J]. Int J Mol Sci, 2021, 22(2): 872. DOI: 10.3390/ijms22020872
|
| [3] |
Tweedell R E, Kanneganti T D. Advances in inflammasome research: recent breakthroughs and future hurdles[J]. Trends Mol Med, 2020, 26(11): 969-971. DOI: 10.1016/j.molmed.2020.07.010
|
| [4] |
Shahzad K, Fatima S, Khawaja H, et al. Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease[J]. Kidney Int, 2022, 102(4): 766-779. DOI: 10.1016/j.kint.2022.06.010
|
| [5] |
Tall AR, Westerterp M. Inflammasomes, neutrophil extracellular traps, and cholesterol[J]. J Lipid Res, 2019, 60(4): 721-727. DOI: 10.1194/jlr.S091280
|
| [6] |
Xiao L, Magupalli V G, Wu H. Cryo-EM structures of the active NLRP3 inflammasome disc[J]. Nature, 2023, 613(7944): 595-600. DOI: 10.1038/s41586-022-05570-8
|
| [7] |
Fu J N, Wu H. Structural mechanisms of NLRP3 inflammasome assembly and activation[J]. Annu Rev Immunol, 2023, 41: 301-316. DOI: 10.1146/annurev-immunol-081022-021207
|
| [8] |
Kayagaki N, Kornfeld O S, Lee B L, et al. NINJ1 mediates plasma membrane rupture during lytic cell death[J]. Nature, 2021, 591(7848): 131-136. DOI: 10.1038/s41586-021-03218-7
|
| [9] |
Evavold C L, Ruan J B, Tan Y H, et al. The pore-forming protein gasdermin D regulates interleukin-1 secretion from living macrophages[J]. Immunity, 2018, 48(1): 35-44. e6. DOI: 10.1016/j.immuni.2017.11.013
|
| [10] |
Liu X, Xia S Y, Zhang Z B, et al. Channelling inflammation: gasdermins in physiology and disease[J]. Nat Rev Drug Discov, 2021, 20(5): 384-405. DOI: 10.1038/s41573-021-00154-z
|
| [11] |
Elias E E, Lyons B, Muruve D A. Gasdermins and pyroptosis in the kidney[J]. Nat Rev Nephrol, 2023, 19(5): 337-350. DOI: 10.1038/s41581-022-00662-0
|
| [12] |
Davie E W, Ratnoff O D. Waterfall sequence for intrinsic blood clotting[J]. Science, 1964, 145(3638): 1310-1312. DOI: 10.1126/science.145.3638.1310
|
| [13] |
Macfarlane R G. An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier[J]. Nature, 1964, 202: 498-499. DOI: 10.1038/202498a0
|
| [14] |
Hoffman M, Monroe D M 3rd. A cell-based model of hemostasis[J]. Thromb Haemost, 2001, 85(6): 958-965. DOI: 10.1055/s-0037-1615947
|
| [15] |
卫凌华, 于潇, 金强, 等. 凝血酶与人类疾病的关系研究进展[J]. 中国实用医刊, 2019, 46(8): 121-125. DOI: 10.3760/cma.j.issn.1674-4756.2019.08.039
Wei L H, Yu X, Jin Q, et al. Research Progress on the Relationship Between Thrombin and Human Diseases[J]. Chin J Pract Med, 2019, 46(8): 121-125. DOI: 10.3760/cma.j.issn.1674-4756.2019.08.039
|
| [16] |
Danese S, Vetrano S, Zhang L, et al. The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications[J]. Blood, 2010, 115(6): 1121-1130. DOI: 10.1182/blood-2009-09-201616
|
| [17] |
Boffa M C. Tissue factor pathway inhibitor: A multifaceted protein beyond its role as an anticoagulant[J]. J Thromb Haemost, 2016, 14(9): 1676-1685.
|
| [18] |
门剑龙, 徐菲亚, 翟振国. 肝素抵抗的发生机制及临床处理策略[J]. 中华医学杂志, 2023, 103(10): 707-713. DOI: 10.3760/cma.j.cn112137-20220830-01838
Men J L, Xu F Y, Zhai Z G. The Mechanisms of Heparin Resistance and Clinical Management Strategies[J]. Zhonghua Yi Xue Za Zhi, 2023, 103(10): 707-713. DOI: 10.3760/cma.j.cn112137-20220830-01838
|
| [19] |
Rezaie A R, Cooper S T, Church F C, et al. Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex[J]. J Biol Chem, 1995, 270(43): 25336-25339. DOI: 10.1074/jbc.270.43.25336
|
| [20] |
Ryan T A J, Preston R J S, O'Neill L A J. Immunothro-mbosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants[J]. Biochem J, 2022, 479(6): 731-750. DOI: 10.1042/BCJ20210522
|
| [21] |
Yamamoto M, Nakagaki T, Kisiel W. Tissue factor-depend-ent autoactivation of human blood coagulation factor Ⅶ[J]. J Biol Chem, 1992, 267(27): 19089-19094. DOI: 10.1016/S0021-9258(18)41745-0
|
| [22] |
Østerud B, Bjørklid E. Sources of tissue factor[J]. Semin Thromb Hemost, 2006, 32(1): 11-23. DOI: 10.1055/s-2006-933336
|
| [23] |
Tang Y T, Wang X Y, Li Z Z, et al. Heparin prevents caspase-11-dependent septic lethality Independent of anticoagulant properties[J]. Immunity, 2021, 54(3): 454-467. e6. DOI: 10.1016/j.immuni.2021.01.007
|
| [24] |
Levi M, Ten Cate H. Disseminated intravascular coagulation[J]. N Engl J Med, 1999, 341(8): 586-592. DOI: 10.1056/NEJM199908193410807
|
| [25] |
Conway E M, Rosenberg R D. Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells[J]. Mol Cell Biol, 1988, 8(12): 5588-5592.
|
| [26] |
Nemerson Y. The phospholipid requirement of tissue factor in blood coagulation[J]. J Clin Invest, 1968, 47(1): 72-80. DOI: 10.1172/JCI105716
|
| [27] |
Potere N, Abbate A, Kanthi Y, et al. Inflammasome signaling, thromboinflammation, and venous thromboembolism[J]. JACC Basic Transl Sci, 2023, 8(9): 1245-1261. DOI: 10.1016/j.jacbts.2023.03.017
|
| [28] |
Rothmeier A S, Marchese P, Petrich B G, et al. Caspase-1-mediated pathway promotes generation of thromboinflam-matory microparticles[J]. J Clin Invest, 2015, 125(4): 1471-1484. DOI: 10.1172/JCI79329
|
| [29] |
Grover S P, Mackman N. Tissue factor: an essential mediator of hemostasis and trigger of thrombosis[J]. Arterioscler Thromb Vasc Biol, 2018, 38(4): 709-725. DOI: 10.1161/ATVBAHA.117.309846
|
| [30] |
Yang X Y, Cheng X Y, Tang Y T, et al. Bacterial endotoxin activates the coagulation cascade through gasdermin Ddependent phosphatidylserine exposure[J]. Immunity, 2019, 51(6): 983-996. e6. DOI: 10.1016/j.immuni.2019.11.005
|
| [31] |
Zhang H, Zeng L, Xie M, et al. TMEM173 drives lethal coagulation in sepsis[J]. Cell Host Microbe, 2020, 27(4): 556-570. e6. DOI: 10.1016/j.chom.2020.02.004
|
| [32] |
Wu C Q, Lu W, Zhang Y, et al. Inflammasome activation triggers blood clotting and host death through pyroptosis[J]. Immunity, 2019, 50(6): 1401-1411. e4. DOI: 10.1016/j.immuni.2019.04.003
|
| [33] |
Martinod K, Wagner D D. Thrombosis: tangled up in NETs[J]. Blood, 2014, 123(18): 2768-2776. DOI: 10.1182/blood-2013-10-463646
|
| [34] |
Cheng K T, Xiong S Q, Ye Z M, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury[J]. J Clin Invest, 2017, 127(11): 4124-4135. DOI: 10.1172/JCI94495
|
| [35] |
Tang Y T, Wang X Y, Li Z Z, et al. Heparin prevents caspase-11-dependent septic lethality Independent of anticoagulant properties[J]. Immunity, 2021, 54(3): 454-467. e6. DOI: 10.1016/j.immuni.2021.01.007
|
| [36] |
Iba T, Levy J H. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis[J]. J Thromb Haemost, 2018, 16(2): 231-241. DOI: 10.1111/jth.13911
|
| [37] |
Zhu C R, Liang Y J, Luo Y T, et al. Role of pyroptosis in hemostasis activation in sepsis[J]. Front Immunol, 2023, 14: 1114917. DOI: 10.3389/fimmu.2023.1114917
|
| [38] |
Coll R C, Hill J R, Day C J, et al. MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition[J]. Nat Chem Biol, 2019, 15(6): 556-559. DOI: 10.1038/s41589-019-0277-7
|
| [39] |
Hu J J, Liu X, Xia S Y, et al. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation[J]. Nat Immunol, 2020, 21(7): 736-745. DOI: 10.1038/s41590-020-0669-6
|
| [40] |
Boxer M B, Quinn A M, Shen M, et al. A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety[J]. ChemMedChem, 2010, 5(5): 730-738. DOI: 10.1002/cmdc.200900531
|
| [41] |
Jing W D, Pilato J L, Kay C, et al. Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins[J]. Sci Immunol, 2022, 7(71): eabm1803. DOI: 10.1126/sciimmunol.abm1803
|
| [42] |
Dong X J, Tu H, Bai X J, et al. Intrinsic/extrinsic apoptosis and pyroptosis contribute to the selective depletion of B cell subsets in septic shock patients[J]. Shock, 2023, 60(3): 345-353.
|
| [43] |
Cheng J B, Liao Y J, Dong Y, et al. Microglial autophagy defect causes Parkinson disease-like symptoms by accelerat-ing inflammasome activation in mice[J]. Autophagy, 2020, 16(12): 2193-2205. DOI: 10.1080/15548627.2020.1719723
|
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