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Volume 14 Issue 1
Jan.  2023
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ZHOU Runing, ZHANG Li, MA Kaiyu, BAO Xiuqi, WANG Weiguo, RUAN Gechong, YANG Hong. Investigation and Risk Factors of Helicobacter pylori Infection in Patients with Inflammatory Bowel Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 124-130. DOI: 10.12290/xhyxzz.2022-0639
Citation: ZHOU Runing, ZHANG Li, MA Kaiyu, BAO Xiuqi, WANG Weiguo, RUAN Gechong, YANG Hong. Investigation and Risk Factors of Helicobacter pylori Infection in Patients with Inflammatory Bowel Disease[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 124-130. DOI: 10.12290/xhyxzz.2022-0639
shu

Investigation and Risk Factors of Helicobacter pylori Infection in Patients with Inflammatory Bowel Disease

  • 1.

    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Gastroenterology, Beijing Shijingshan Hospital, Shijingshan Teaching Hospital of Capital Medical University, Beijing 100043, China

  • 3.

    Department of Medical Affairs, Jiamusi Central Hospital, Jiamusi, Heilongjiang 154002, China

  • 4.

    Department of Gastroenterology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, China

  • 5.

    Department of Gastroenterology, Dezhou Municiple Hospital, Dezhou, Shandong 253012, China

Funds: 

National Key Clinical Specialty Construction Project ZK108000

CAMS Innovation Fund for Medical Sciences 2022-I2M-C&T-B-011

National High-level Hospital Clinical Research Funding 2022-PUMCH-C-018

More Information
  • Corresponding author:

    RUAN Gechong, E-mail: ruangechong@pumch.cn

  • Received Date: November 08, 2022
  • Accepted Date: December 05, 2022
  • Issue Publish Date: January 29, 2023
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the rate and risk factors of Helicobacter pylori(Hp) infection in patients with inflammatory bowel disease(IBD).
      Methods  A survey was conducted from January 1, 2020 to December 31, 2020 by sending an electronic questionnaire to long-term follow-up IBD patients of Peking Union Medical College Hospital and age-sex-matched Beijing community residents. General information, information related to Hp infection and environmental factors were collected from the two groups. The differences in Hp positivity rates between the two groups and IBD patients with different clinical profiles were compared.
      Results  After propensity score matching, 122 patients with IBD and 1739 community residents were finally included in this study. The histograms of propensity score values were highly consistent between the two groups. The ratio of Hp infection was significantly lower in IBD patients than in the community residents (13.1% vs. 42.7%, P < 0.001). The ratio of Hp infection in both groups increased with age but showed no statistical significance (all P > 0.05). Univariate analysis showed that the IBD patients with Hp positive co-diners had a significantly higher ratio of Hp infection than those with Hp negative co-diners (43.8% vs. 18.9%, P=0.006).
      Conclusions  The Hp infection rate was lower in IBD patients than in community residents. The possible risk factor may be co-dining with Hp positives.
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    • References (23)
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