Skip to main content
Springer Nature Link
Log in

Unlocking the Mysteries of the Subcommissural Organ: A Patron Saint of Neuronal Development

  • Research Highlight
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Kaur C, Ling EA. The circumventricular organs. Histol Histopathol 2017, 32: 879–892.

    PubMed  Google Scholar 

  2. Rodríguez EM, Rodríguez S, Hein S. The subcommissural organ. Microsc Res Techniq 1998, 41: 98–123.

    Article  Google Scholar 

  3. Caprile T, Hein S, Rodríguez S, Montecinos H, Rodríguez E. Reissner fiber binds and transports away monoamines present in the cerebrospinal fluid. Brain Res Mol Brain Res 2003, 110: 177–192.

    Article  PubMed  CAS  Google Scholar 

  4. Inada H, Corales LG, Osumi N. A novel feature of the ancient organ: A possible involvement of the subcommissural organ in neurogenic/gliogenic potential in the adult brain. Front Neurosci 2023, 17: 1141913.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F. The subcommissural organ regulates brain development via secreted peptides. Nat Neurosci 2024, 27: 1103–1115.

    Article  PubMed  CAS  Google Scholar 

  6. Roth LW, Bormann P, Bonnet A, Reinhard E. Beta-thymosin is required for axonal tract formation in developing zebrafish brain. Development 1999, 126: 1365–1374.

    Article  PubMed  CAS  Google Scholar 

  7. Duy PQ, Weise SC, Marini C, Li XJ, Liang D, Dahl PJ, et al. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nat Neurosci 2022, 25: 458–473.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

Download references

Acknowledgements

This research highlight was supported by the National Natural Science Foundation of China (2070974, 32371003) and the Key R&D Program of Zhejiang Province, China (2021R52021).

Author information

Authors and Affiliations

  1. Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine, Zhejiang University School of Medicine, Hangzhou, 310058, China

    Yuxiang Luo, Weiying Wu & Zhihua Gao

  2. Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain-machine Integration, State Key Laboratory of Brain-machine Intelligence, Zhejiang University Medical Center, Zhejiang University, Hangzhou, 311121, China

    Yuxiang Luo, Weiying Wu & Zhihua Gao

  3. NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University, Hangzhou, 310058, China

    Yuxiang Luo, Weiying Wu & Zhihua Gao

Authors
  1. Yuxiang Luo
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Weiying Wu
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Zhihua Gao
    View author publications

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Zhihua Gao.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Luo, Y., Wu, W. & Gao, Z. Unlocking the Mysteries of the Subcommissural Organ: A Patron Saint of Neuronal Development. Neurosci. Bull. 40, 2012–2014 (2024). https://doi.org/10.1007/s12264-024-01290-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-024-01290-3