The effects of Eugenia jambolana extract on streptozotocin-induced pancreatic islet destruction in rats Dhanush B.2, Krishna1,2,*, Rao Suguna2, Satyanarayana M.L.2, Byregowda S.M.2 2Department of Veterinary Pathology, Institute of Animal Health and Veterinary Biologicals, Bangalore-560 024, Karnataka 1Department of Veterinary Pathology, College of Veterinary and Animal Sciences, KVASU, Mannuthy, Thrissur-680651, Kerala *Corresponding author: email: dhanushkb@gmail.com
Abstract The study was undertaken to investigate the relationship and effects of Eugenia jambolana (EJ) extract on pancreas morphology, architecture and function in streptozotocin (STZ) induced diabetic rats. Experimental diabetes mellitus was induced in Wistar rats with single intraperitoneal administration of STZ (45mg/kg). The rats were separated into four groups as follows: Group I served as normal control and group II served as diabetic control. Group III and IV served as diabetic and administered with 200 mg/kg of EJ extract and 0.6 mg/kg of glibenclamide orally once daily for 45 days, respectively. Light microscopic evaluation of islets of Langerhans showed highly swollen P- cells with loss of cytoplasmic granularity, vacuolations, necrosis, elongated P-cells and sparse cellularity in diabetic rats. There were also significant (P<0.01) increase in blood glucose, serum cholesterol and triglyceride and decrease in serum insulin, body weight and haemoglobin level in diabetic rats. Treatment of diabetic rats with EJ significantly (P<0.01) improved the condition compared to diabetic control rats. The STZ induced microscopical changes in pancreas were ameliorated by EJ extract which was also consistent with biochemical observations. These results suggest that EJ extract has potential hypoglycaemic effects in diabetic rats. Top Keywords Eugenia jambolana, Histopathology, Hypoglycaemic, Pancreas, Streptozotocin. Top |