2000—2023年国际老年人共病研究文献计量学分析

张宁, 张晓辰, 何牧, 孙晓红, 康琳, 曲璇, 朱鸣雷

张宁, 张晓辰, 何牧, 孙晓红, 康琳, 曲璇, 朱鸣雷. 2000—2023年国际老年人共病研究文献计量学分析[J]. 协和医学杂志, 2024, 15(4): 867-876. DOI: 10.12290/xhyxzz.2023-0516
引用本文: 张宁, 张晓辰, 何牧, 孙晓红, 康琳, 曲璇, 朱鸣雷. 2000—2023年国际老年人共病研究文献计量学分析[J]. 协和医学杂志, 2024, 15(4): 867-876. DOI: 10.12290/xhyxzz.2023-0516
ZHANG Ning, ZHANG Xiaochen, HE Mu, SUN Xiaohong, KANG Lin, QU Xuan, ZHU Minglei. A Bibliometric Analysis of the Global Research on Multimorbidity in Older Adults from 2000 to 2023[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 867-876. DOI: 10.12290/xhyxzz.2023-0516
Citation: ZHANG Ning, ZHANG Xiaochen, HE Mu, SUN Xiaohong, KANG Lin, QU Xuan, ZHU Minglei. A Bibliometric Analysis of the Global Research on Multimorbidity in Older Adults from 2000 to 2023[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(4): 867-876. DOI: 10.12290/xhyxzz.2023-0516

2000—2023年国际老年人共病研究文献计量学分析

基金项目: 

中央高水平医院临床科研专项 2022-PUMCH-B-132

详细信息
    通讯作者:

    孙晓红,E-mail:sunxiaoh2010@126.com

  • 中图分类号: R592; R181.2

A Bibliometric Analysis of the Global Research on Multimorbidity in Older Adults from 2000 to 2023

Funds: 

National High Level Hospital Clinical Research 2022-PUMCH-B-132

More Information
  • 摘要:
    目的 

    分析2000—2023年老年人共病领域的国际研究趋势及前沿热点,以期为老年人共病研究提供借鉴。

    方法 

    检索Web of Science数据库,将文献类型限制为“Article”或“Review”,纳入发表时间为2000年1月1日—2023年10月24日的老年人共病相关英文文献。采用VOSviewer 1.6.18软件对文献中的内容进行提取,并绘制高产国家/地区(发文量≥30篇)、机构(发文量≥43篇)的合作网络图及高频关键词(出现频次≥74次)的共现关系时间线图。采用CiteSpace 6.1.R6软件对作者、研究机构、国家等信息进行共现和聚类分析。采用R语言“bibliometrix”包分析文献的关键词演变趋势。

    结果 

    共获得老年人共病相关文献2590篇(包括Article 2230篇、Review 360篇)。自2000年以来全球发文量快速增长,美国在该领域的发文量(35.02%,907/2590)及总被引频次(31 343次)均最多。加拿大多伦多大学的发文量最大(2.59%,67/2590),加拿大麦克马斯特大学的Jenny Ploeg(1.24%,32/2590)是成果产出最多的作者。BMC Geriatr(3.82%,99/2590)是收录老年人共病相关文献最多的期刊。该领域高频关键词主要为“multimorbidity”“older adults”“frailty”“aging”和“polypharmacy”。

    结论 

    近年来,老年人共病研究的热点主要集中于老年人共病与衰老的关系,以及与共病相关的衰弱和多重用药方面。未来可更多围绕老年综合评估、初级卫生保健以及生活质量等内容展开研究。

    Abstract:
    Objective 

    To analyze the research trends and cutting-edge hot spots in the field of multimorbidity in older adults from 2000 to 2023 to provide reference for related research.

    Methods 

    We conducted a search in the Web of Science Core Collection database, specifically looking for articles or reviews in English on multimorbidity in older adults published between January 1, 2000 and October 24, 2023. VOSviewer 1.6.18 software was used to extract the contents in the literature and draw the cooperative network diagram of high-producing countries(≥30 articles) and institutions(≥43 articles) as well as the timeline diagram of high-frequency keywords(≥74 occurrences) co-occurrence relationship. CiteSpace 6.1.R6 software was used to co-occur and cluster analyze the information of authors, research institutions and countries. The "bibliometrix" package in R was used to analyze the evolution of keywords in the literature.

    Results 

    A total of 2590 documents consisting of 2230 Articles and 360 Reviews were obtained. The worldwide publication count significantly increased since 2000. Among the countries, the United States had the highest number of publications (35.02%, 907/2590) and total citations(31 343 times) in this field. The University of Toronto in Canada had the largest number of articles(2.59%, 67/2590). Jenny Ploeg of McMaster University was recognized as the most prolific author(1.24%, 32/2590). When it came to journals, BMC Geriatrics had the highest amount of literature related to multimorbidity(3.82%, 99/2590). The key areas of research in this field included multimorbidity, older adults, frailty, aging, and polypharmacy. Notably, there was growing interest in studying the relationship between multimorbidity and aging in older adults, as well as the impact of frailty and polypharmacy on multimorbidities.

    Conclusions 

    In recent years, research on multimorbidities in the elderly has primarily centered around examining the correlation between comorbidities and aging, as well as exploring the impact of frailty and polypharmacy on individuals with multimorbidities. Future research could delve into primary health care, comprehensive geriatric assessment for older adults with multimorbidities, and maintenance of their overall quality of life.

  • Dieulafoy病由法国医生Dieulafoy于1898年首次提出,是一种相对罕见但可能危及生命的疾病,该病可能发生异常黏膜下小动脉(又称黏膜下恒径动脉,最常见于胃黏膜)出血,进而导致严重的胃肠道出血。而支气管Dieulafoy病则更为罕见,直至1995年才由Sweerts等[1]首次报道,其典型特征为支气管黏膜下存在1条发育异常的动脉[2],多数患者由于反复咯血或支气管镜下活检不慎而导致大出血,通过血管造影术或病理诊断而确诊。然而,有多例报道因支气管镜下活检而导致患者大出血死亡[3-4],严重威胁患者生命安全。与血管造影术及病理诊断相比,支气管内超声(endobronchial ultrasound, EBUS)及彩色多普勒血流显像具有无创、安全且更加简单易行的优点,该病在胸部增强CT动脉期可见异常动脉血管强化以及支气管黏膜下病灶超声特征、血流情况,能够区分血管或实性病变。本文报道1例采用胸部增强CT结合EBUS诊断的支气管Dieulafoy病,并结合相关文献对该病的临床表现、病理特点及治疗进行分析,以提高临床医生对该疾病的认识,防止行支气管镜下活检而导致严重出血,探索更为安全有效的临床诊断方法。

    患者男性,56岁,于2021年6月10日体检时行胸部CT平扫发现肺窗左主支气管内结节样新生物(直径约为0.5 cm),肺窗及纵隔窗皆可见(图 1A1B)。患者身体健康,偶有咳嗽,少量白痰,无咯血、痰中带血、胸痛等不适。既往史:每日吸烟40支,持续吸烟40余年。于当地医院行支气管镜检查,见左主支气管远端新生物,未行活检,为进一步诊治于2021年7月2日就诊于北京协和医院呼吸与危重症医学科。门诊行胸部增强CT示左主支气管内结节样新生物,突入管腔的部分动脉期强化明显(图 1C),行支气管镜检查示左主支气管远端黄豆粒大小结节样黏膜隆起,表面光滑,可见细小血管,未见搏动(图 1D),支气管内超声探查该隆起部位黏膜下为粗大血管,可见明显彩色血流信号(图 1E)。根据上述表现考虑诊断为支气管Dieulafoy病,为避免引发大出血,未行支气管镜下活检。

    图  1  患者影像学检查结果
    A、B.胸部CT平扫;C.胸部增强CT扫描;D.支气管镜检查;E.支气管内超声检查

    以“Dieulafoy's disease ”“bronchial Dieulafoy's disease”“支气管Dieulafoy病”“Dieulafoy病”为检索词,在PubMed、万方数据知识服务平台和中国知网数据库进行文献检索,检索时间为2010年1月至2022年7月,并进行文献复习。

    目前支气管Dieulafoy病的发病机制尚不清楚,多数学者认为,该疾病属于先天性发育不良,且大部分患者有吸烟史或呼吸道疾病史,因此该病可能与长期吸烟或慢性感染所致的气道慢性炎症或损伤有关。该病的临床特点为男性多于女性(比例约为2∶1),中年人发病率较高,右肺的发生率高于左肺[5-6]

    临床表现方面,该疾病不具有特异性,临床症状主要包括反复咯血、咳嗽、气短、胸部不适等,也可无任何症状表现而在体检时发现。大多数患者出现咯血症状[3],其原因可能是由炎症或损伤等外部因素所致,也可能是自发破裂出血,但高血压、糖尿病、心血管疾病或其他因素是否参与其中,目前尚不清楚[7]

    辅助检查方面:(1) 病理诊断虽作为支气管Dieulafoy病诊断的金标准,术后病理或尸检提示支气管黏膜下结缔组织纤维内可见含弹力纤维的小动脉血管壁,但因活检具有潜在致死性,其必要性目前尚存有争议[8-9]。有研究报道19例支气管Dieulafoy病患者通过支气管活检进行病理诊断,仅5例可见动脉血管壁,17例发生出血,其中6例死亡[3]。(2)胸部CT平扫可表现为磨玻璃影、结节影、肺炎样渗出等。有病例报道,胸部CT平扫表现为肿块样改变、阻塞性肺不张,支气管镜检查发现管腔狭窄、黏膜肿胀,行活检后发生大出血,行支气管动脉栓塞术可见病灶处迂曲血管,最终因广泛血管内凝血及多器官功能衰竭而死亡[4]。(3)支气管镜检查更加直观,但镜下表现多种多样。一项纳入64例患者的研究显示,支气管镜下Dieulafoy病常表现为结节样隆起(39/64)、出血点或血凝块(15/64),仅1例病灶处为白色小点,2例表现为正常黏膜[3]。(4)对于怀疑Dieulafoy病的患者,可行胸部增强CT进一步明确病灶中是否存在血管强化,胸部增强CT动脉期可见异常动脉血管的强化,也能评估病灶及周围组织血供情况。(5)支气管动脉造影可见迂曲的肺内血管畸形、支气管动脉扩张、动脉异常、血管分流、瘘管和造影剂外渗入肺部,但无法显示肺动脉病变[10-11]。(6)目前,已有多项研究报道EBUS检查可见支气管黏膜下病灶的血流情况,能够区分血管性病变或实性病灶,有效诊断支气管Dieulafoy病[12-16]。对于黏膜结节样隆起性病变,如黏膜表面正常,可先行EBUS检查,如病灶黏膜下存在粗大彩色血流信号,则可辅助诊断,避免因盲目活检而导致的致死性大出血,但常规EBUS镜头难以到达上叶及远端支气管,可采用超声小探头支气管镜技术(radial endobronchial ultrasound, R-EBUS)实现这一操作[8],由于EBUS检查同样会对支气管壁有摩擦,对于有大咯血的患者,不建议行EBUS检查[17]

    目前,主要是针对出现咯血症状的支气管Dieulafoy病患者进行治疗,对于无咯血症状的患者可暂行观察或保守治疗。Qian等[3]报道70例支气管Dieulafoy病患者,其中7例未出现咯血症状。贾卫红等[18]报道30例支气管Dieulafoy病患者,其中26例发生咯血,其余4例无咯血症状,30例患者均进行支气管检查,多数行支气管动脉造影,检查结果显示局部黏膜隆起5例,结节样改变25例(其中光滑结节21例,桑葚样结节、蓝色蚯蚓状凸起、息肉样和新生物样结节各1例)。杨瑞红等[19]报道的22例支气管Dieulafoy病患者中15例发生大咯血。对于支气管出血患者,虽反复出血但出血量不大,可经气管镜行氩等离子电凝止血治疗[20-21]。对于大咯血患者,由于出血来源于动脉,出血速度快且出血量较大,可行支气管动脉栓塞术或支气管电凝止血[7],但支气管动脉栓塞术成功率仅为71%[5],原因可能是支气管Dieulafoy病的动脉来源除大部分为支气管动脉,少部分来自于肺动脉[19],行支气管动脉栓塞术后,有可能血管再通导致再次出血,如果手术失败,可考虑行肺叶切除根治术[7]

    综上,由于支气管Dieulafoy病报道较少,易被忽视,对于不明原因咯血患者,应注意筛查该病,支气管动脉造影能够对该病进行诊断,且通过支气管动脉栓塞术达到治疗目的;对于未发生咯血的患者,仅有咳嗽等轻微症状,或通过体检及支气管镜检查时发现病灶,如支气管镜检查有主气道结节样新生物,如表面光滑、表面分布血管、可见搏动,可采用胸部增强CT扫描结合EBUS探查病灶支气管黏膜下血流情况,能够有效诊断支气管Dieulafoy病,避免因盲目活检而导致大出血风险,此方法无创、安全且有效易行,值得临床推广应用。

    作者贡献:张宁负责论文构思、数据分析、论文撰写;张晓辰负责文献检索、文献筛选、数据分析;何牧负责文献筛选、数据分析;康琳、曲璇、朱鸣雷负责文献检索及论文修订;孙晓红负责论文修订与审核。
    利益冲突:所有作者均声明不存在利益冲突
  • 图  1   2590篇老年人共病研究文献年发文量及被引频次分布情况

    Figure  1.   Distribution of annual publications and citation frequency of 2590 co-morbidity research literature on older adults

    图  2   发文量≥30篇的国家/地区合作网络图

    注:各节点间的连线表明二者存在合作关系,连线越粗表示合作关系越强。美国所代表的红色条带宽度、与其他条带的连接宽度均最大

    Figure  2.   Map of cooperation network of countries/regions with ≥30 publications

    图  3   发文量居前10位的研究机构合作网络图

    Figure  3.   Collaborative network map of the top 10 research institutions in terms of number of publications

    表  1   发文量、连接强度、被引频次居前10位的国家

    Table  1   Top 10 countries in terms of number of publications, link strength and frequency of citations

    序号 国家 发文量(篇) 国家 连接强度 国家 被引频次(次)
    1 美国 907 英国 396 美国 31 343
    2 英国 240 美国 371 英国 10099
    3 加拿大 228 意大利 323 意大利 9258
    4 意大利 206 西班牙 300 荷兰 7193
    5 荷兰 200 荷兰 278 加拿大 7191
    6 德国 191 德国 254 德国 5782
    7 中国 185 澳大利亚 243 瑞典 5086
    8 西班牙 184 法国 193 瑞士 4462
    9 澳大利亚 183 加拿大 170 西班牙 3944
    10 瑞典 105 比利时 170 澳大利亚 3693
    下载: 导出CSV

    表  2   发文量、被引频次及共被引频次居前10位的作者

    Table  2   Top 10 authors in terms of number of publications, citation frequency and co-citation frequency

    序号 作者 发文量(篇) 作者 被引频次(次) 作者 共被引频次(次)
    1 Jenny Ploeg 32 Alessandra Marengoni 3491 Alessandra Marengoni 566
    2 Maureen Markle-Reid 29 Laura Fratiglioni 2794 Linda P Fried 496
    3 Davide L.Vetrano 29 Susan M.Smith 1419 Martin Fortin 437
    4 Alessandra Marengoni 28 Graziano Onder 1186 Mary E.Charlson 425
    5 Cynthia M.Boyd 22 Martin Fortin 1123 World Health Organization 400
    6 Amaia Calderon-Larranaga 22 Davide L.Vetrano 997 Cynthia M.Boyd 357
    7 Graziano Onder 22 Cynthia M.Boyd 972 Karen Barnett 342
    8 Laura Fratiglioni 21 Jenny Ploeg 963 Mary E Tinetti 335
    9 Ai Koyanagi 17 Maureen Markle-Reid 815 Martine Exterman 293
    10 Kathryn Fisher 16 Emma Wallace 799 Ronald C.Kessler 273
    下载: 导出CSV

    表  3   发文量、总连接强度、被引频次居前10位的研究机构

    Table  3   Top 10 research institutions in terms of number of publications, total link strength and citation frequency

    序号 机构名称 发文量(篇) 机构名称 总连接强度 机构名称 被引频次(次)
    1 多伦多大学 67 卡罗林斯卡学院 164 卡罗林斯卡学院 4128
    2 卡罗林斯卡学院 63 多伦多大学 135 哥伦比亚大学 3640
    3 麦克马斯特大学 53 斯德哥尔摩大学 125 布雷西亚大学 3552
    4 约翰斯·霍普金斯大学 51 约翰斯·霍普金斯大学 117 约翰斯·霍普金斯大学 3343
    5 华盛顿大学 50 杜克大学 115 斯德哥尔摩大学 3055
    6 密歇根州立大学 49 加利福尼亚大学旧金山分校 114 斯德哥尔摩老年研究中心 2830
    7 杜克大学 47 布雷西亚大学 102 伦敦卫生与热带医学院 2731
    8 加利福尼亚大学旧金山分校 45 哈佛医学院 100 印第安纳大学 2653
    9 悉尼大学 45 圣心天主教大学 96 拉德堡德大学 2570
    10 伦敦国王学院 43 斯德哥尔摩老年研究中心 94 匹兹堡大学 2134
    下载: 导出CSV

    表  4   发文量、被引频次居前10位的期刊

    Table  4   Top 10 journals in terms of number of publications and frequency of citations

    序号 期刊 发文量(篇) 影响因子(JCR2022) JCR分区 共被引期刊 被引频次(次) 影响因子(JCR2022) JCR分区
    1 BMC Geriatr 99 4.1 Q2 J Am Geriatr Soc 4037 6.3 Q1
    2 J Am Geriatr Soc 67 6.3 Q1 J Gerontol A Biol Sci Med Sci 2164 5.1 Q2
    3 BMJ Open 56 2.9 Q2 J Am Med Assoc 2144 120.7 Q1
    4 Arch Gerontol Geriatr 53 4 Q2 J Clin Oncol 2105 45.4 Q1
    5 J Geriatr Oncol 53 3 Q3 Lancet 1829 168.9 Q1
    6 PLoS One 50 3.7 Q2 PLoS One 1815 3.7 Q2
    7 Age Ageing 46 6.7 Q1 J Clin Epidemiol 1781 7.2 Q1
    8 Int J Environ Res Public Health 36 NA NA New Engl J Med 1431 158.5 Q1
    9 J Gerontol A Biol Sci Med Sci 34 5.1 Q2 Age Ageing 1382 6.7 Q1
    10 J Am Med Dir Assoc 33 7.6 Q1 Blood 1193 20.3 Q1
    下载: 导出CSV

    表  5   出现频次、总连接强度居前20位的关键词

    Table  5   Top 20 keywords in terms of frequency of occurrenceand total link strength

    序号 关键词 出现频次(次) 总连接强度
    1 multimorbidity 1172 2194
    2 older adults 886 1706
    3 frailty 206 468
    4 aging 153 301
    5 polypharmacy 138 312
    6 depression 137 294
    7 chronic disease 134 302
    8 mortality 124 261
    9 geriatric assessment 83 200
    10 quality of life 80 188
    11 cancer 75 213
    12 dementia 74 145
    13 epidemiology 70 132
    14 disability 68 145
    15 comprehensive geriatric assessment 62 151
    16 geriatrics 60 144
    17 primary care 58 116
    18 anxiety 54 118
    19 geriatric oncology 46 123
    20 geriatric 44 102
    下载: 导出CSV

    表  6   被引频次居前15位的文献

    Table  6   Top 15 cited articles

    序号 作者及发表时间 文章题目 期刊名称 被引频次(次) 文章类别
    1 Moussavi S等(2007年) Depression, chronic diseases, and decrements in health: results from the World Health Surveys Lancet 2586 Article
    2 Kroenke K等(2009年) The PHQ-8 as a measure of current depression in the general population J Affect Disord 2575 Article
    3 Marengoni A等(2011年) Aging with multimorbidity: A systematic review of the literature Ageing Res Rev 1645 Review
    4 Wolff JL等(2002年) Prevalence, expenditures, and complications of multiple chronic conditions in the elderly Arch Intern Med 1480 Article
    5 Diniz BS等(2013年) Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies Br J Psychiatry 763 Review
    6 Repetto L等(2002年) Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: An Italian group for geriatric oncology study J Clin Oncol 676 Article
    7 Salive ME(2013年) Multimorbidity in Older Adults Epidemiol Rev 669 Article
    8 Lehnert T等(2011年) Health Care Utilization and Costs of Elderly Persons With Multiple Chronic Conditions Med Care Res Rev 468 Review
    9 Hanlon P等(2018年) Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants Lancet Public Health 441 Article
    10 Byers AL等(2010年) High Occurrence of Mood and Anxiety Disorders Among Older Adults The National Comorbidity Survey Replication Arch Gen Psychiatry 428 Article
    11 Quoix E等(2011年) Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: IFCT-0501 randomised, phase 3 trial Lancet 417 Article
    12 Diederichs C等(2011年) The measurement of multiple chronic diseases--a systematic review on existing multimorbidity indices J Gerontol A Biol Sci Med Sci 413 Review
    13 Smith SM等(2012年) Managing patients with multimorbidity: systematic review of interventions in primary care and community settings BMJ 396 Article
    14 Björgvinsson T等(2013年) Psychometric properties of the CES-D-10 in a psychiatric sample Assessment 389 Article
    15 Smith SM等(2016年) Interventions for improving outcomes in patients with multimorbidity in primary care and community settings Cochrane DatabaseSyst Rev 384 Review
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  • [1] 闫伟, 路云, 张冉, 等. 基于CHARLS数据分析的我国老年人共病现状研究[J]. 中华疾病控制杂志, 2019, 23(4): 426-430. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ201904013.htm

    Yan W, Lu Y, Zhang R, et al. Multimorbidity status of the elderly in China-research based on CHARLS data[J]. Chin J Dis Control Prev, 2019, 23(4): 426-430. https://www.cnki.com.cn/Article/CJFDTOTAL-JBKZ201904013.htm

    [2]

    Xu X L, Mishra G D, Jones M. Evidence on multimorbidity from definition to intervention: an overview of systematic reviews[J]. Ageing Res Rev, 2017, 37: 53-68. DOI: 10.1016/j.arr.2017.05.003

    [3]

    Kivimäki M, Strandberg T, Pentti J, et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study[J]. Lancet Diabetes Endocrinol, 2022, 10(4): 253-263. DOI: 10.1016/S2213-8587(22)00033-X

    [4]

    The Emerging Risk Factors Collaboration. Association of cardiometabolic multimorbidity with mortality[J]. JAMA, 2015, 314(1): 52-60. DOI: 10.1001/jama.2015.7008

    [5]

    Vetrano D L, Rizzuto D, Calderón-Larra aga A, et al. Trajectories of functional decline in older adults with neuropsychiatric and cardiovascular multimorbidity: a Swedish cohort study[J]. PLoS Med, 2018, 15(3): e1002503. DOI: 10.1371/journal.pmed.1002503

    [6] 王丽敏, 陈志华, 张梅, 等. 中国老年人群慢性病患病状况和疾病负担研究[J]. 中华流行病学杂志, 2019, 40(3): 277-283.

    Wang L M, Chen Z H, Zhang M, et al. Study of the prevalence and disease burden of chronic disease in the elderly in China[J]. Chin J Epidemiol, 2019, 40(3): 277-283.

    [7]

    La D T V, Zhao Y, Arokiasamy P, et al. Multimorbidity and out-of-pocket expenditure for medicines in China and India[J]. BMJ Glob Health, 2022, 7(11): e007724. DOI: 10.1136/bmjgh-2021-007724

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    Muth C, Blom J W, Smith S M, et al. Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus[J]. J Intern Med, 2019, 285(3): 272-288. DOI: 10.1111/joim.12842

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    Liu W M, Wu J Y, Zhang N, et al. Postural deformities in Parkinson's disease: a bibliometric analysis based on web of science[J]. Heliyon, 2023, 9(3): e14251. DOI: 10.1016/j.heliyon.2023.e14251

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    Van Eck N J, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping[J]. Scientometrics, 2010, 84(2): 523-538. DOI: 10.1007/s11192-009-0146-3

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    Zhou J, Song D, Ma J J, et al. Research trends in the mental health and multimorbidity of older people from 2002 to 2022: a bibliometric analysis via CiteSpace[J]. Front Psychiatry, 2023, 14: 1117554. DOI: 10.3389/fpsyt.2023.1117554

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    Wang L Y, Luo D, Hamdaoui O, et al. Bibliometric analysis and literature review of ultrasound-assisted degradation of organic pollutants[J]. Sci Total Environ, 2023, 876: 162551. DOI: 10.1016/j.scitotenv.2023.162551

    [13]

    Ye B Q, Xie R X, Mishra S R, et al. Bidirectional association between physical multimorbidity and subclinical depression in Chinese older adults: findings from a prospective cohort study[J]. J Affect Disord, 2022, 296: 169-174. DOI: 10.1016/j.jad.2021.09.067

    [14]

    Moussavi S, Chatterji S, Verdes E, et al. Depression, chronic diseases, and decrements in health: results from the World Health Surveys[J]. Lancet, 2007, 370(9590): 851-858. DOI: 10.1016/S0140-6736(07)61415-9

    [15]

    Triolo F, Sjöberg L, Calderón-Larrañaga A, et al. Late-life depression and multimorbidity trajectories: the role of symptom complexity and severity[J]. Age Ageing, 2023, 52(2): afac315. DOI: 10.1093/ageing/afac315

    [16]

    Kroenke K, Strine T W, Spitzer R L, et al. The PHQ-8 as a measure of current depression in the general population[J]. J Affect Disord, 2009, 114(1/3): 163-173.

    [17]

    Marengoni A, Angleman S, Melis R, et al. Aging with multimorbidity: a systematic review of the literature[J]. Ageing Res Rev, 2011, 10(4): 430-439. DOI: 10.1016/j.arr.2011.03.003

    [18]

    Schiltz N K. Prevalence of multimorbidity combinations and their association with medical costs and poor health: a population-based study of U.S. adults[J]. Front Public Health, 2022, 10: 953886. DOI: 10.3389/fpubh.2022.953886

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    Li H F, Chang E X, Zheng W J, et al. Multimorbidity and catastrophic health expenditure: evidence from the China Health and Retirement Longitudinal Study[J]. Front Public Health, 2022, 10: 1043189. DOI: 10.3389/fpubh.2022.1043189

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    Guo X R, Zhao B H, Chen T M, et al. Multimorbidity in the elderly in China based on the China Health and Retirement Longitudinal Study[J]. PLoS One, 2021, 16(8): e0255908. DOI: 10.1371/journal.pone.0255908

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    Zheng D D, Loewenstein D A, Christ S L, et al. Multimorbidity patterns and their relationship to mortality in the US older adult population[J]. PLoS One, 2021, 16(1): e0245053. DOI: 10.1371/journal.pone.0245053

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    American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Guiding principles for the care of older adults with multimorbidity: an approach for clinicians[J]. J Am Geriatr Soc, 2012, 60(10): E1-E25.

    [23]

    Boyd C, Smith C D, Masoudi F A, et al. Decision making for older adults with multiple chronic conditions: executive summary for the American Geriatrics Society guiding principles on the care of older adults with multimorbidity[J]. J Am Geriatr Soc, 2019, 67(4): 665-673. DOI: 10.1111/jgs.15809

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    Fraser H C, Kuan V, Johnen R, et al. Biological mechanisms of aging predict age-related disease co-occurrence in patients[J]. Aging Cell, 2022, 21(4): e13524. DOI: 10.1111/acel.13524

    [25]

    Salvioli S, Basile M S, Bencivenga L, et al. Biomarkers of aging in frailty and age-associated disorders: state of the art and future perspective[J]. Ageing Res Rev, 2023, 91: 102044. DOI: 10.1016/j.arr.2023.102044

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    Luo Y, Chen Y M, Wang K P, et al. Associations between multimorbidity and frailty transitions among older Americans[J]. J Cachexia Sarcopenia Muscle, 2023, 14(2): 1075-1082. DOI: 10.1002/jcsm.13197

    [27]

    Hanlon P, Nicholl B I, Jani B D, et al. Frailty and pre-frailty in middle-aged and older adults and its association with multimorbidity and mortality: a prospective analysis of 493 737 UK Biobank participants[J]. Lancet Public Health, 2018, 3(7): e323-e332. DOI: 10.1016/S2468-2667(18)30091-4

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    Lipska K J, Krumholz H, Soones T, et al. Polypharmacy in the aging patient: a review of glycemic control in older adults with type 2 diabetes[J]. JAMA, 2016, 315(10): 1034-1045. DOI: 10.1001/jama.2016.0299

    [29] 陈旭娇, 严静, 王建业, 等. 老年综合评估技术应用中国专家共识[J]. 中华老年医学杂志, 2017, 36(5): 471-477. https://www.cnki.com.cn/Article/CJFDTOTAL-LNBY201702001.htm

    Chen X J, Yan J, Wang J Y, et al. Chinese experts consensus on application of comprehensive geriatric assessment[J]. Chin J Geriatr, 2017, 36(5): 471-477. https://www.cnki.com.cn/Article/CJFDTOTAL-LNBY201702001.htm

  • 期刊类型引用(1)

    1. 刘敏,杨金苹,赵金颜,乔建红. 老年共病患者自我感知老化、抑郁情绪与生活质量的相关性研究. 心理月刊. 2024(21): 58-60 . 百度学术

    其他类型引用(0)

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出版历程
  • 收稿日期:  2023-11-01
  • 录用日期:  2023-11-27
  • 网络出版日期:  2023-12-08
  • 发布日期:  2023-12-07
  • 刊出日期:  2024-07-29

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