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Volume 14 Issue 5
Sep.  2023
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HUANG Biqing, LI Lanjuan. The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 939-944. DOI: 10.12290/xhyxzz.2023-0173
Citation: HUANG Biqing, LI Lanjuan. The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(5): 939-944. DOI: 10.12290/xhyxzz.2023-0173
shu

The Impact of Gut Microbiota on Vaccine Immune Efficacy and Potential Mechanisms

  • 1.

    Research Units of Infectious Disease and Microecology, Chinese Academy of Medical Sciences & Peking Union Medical College, Hangzhou 310003, China

  • 2.

    NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 102600, China

  • 3.

    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

Funds: 

CAMS Innovation Fund for Medical Sciences 2019-I2M- 5- 045

More Information
  • Corresponding author:

    LI Lanjuan, E-mail: ljli@zju.edu.cn

  • Received Date: April 02, 2023
  • Accepted Date: May 28, 2023
  • Available Online: May 31, 2023
  • Issue Publish Date: September 29, 2023
    Graphical Abstract
    • Abstract
  • Vaccine is the most effective method to prevent the spread of communicable diseases, but the immune response it induces varies significantly among individuals and populations in different regions. Recent studies have shown that the composition and function of the gut microbiota play a key role in the immune response following vaccination. This article aims to explain the differences in gut microbiota among different vaccinated populations and animals, discuss how the gut microbiota affects the immune efficacy of the vaccine, and summarize strategies for targeting the gut microbiota to improve vaccine efficacy.
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    • References (36)
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