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Volume 13 Issue 2
Mar.  2022
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CHENG Yuejuan, GUAN Mei, WANG Xiang, BAI Chunmei. Novel Treatment Strategies for Advanced Pancreatic Ductal Adenocarcinoma[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 341-348. DOI: 10.12290/xhyxzz.2021-0139
Citation: CHENG Yuejuan, GUAN Mei, WANG Xiang, BAI Chunmei. Novel Treatment Strategies for Advanced Pancreatic Ductal Adenocarcinoma[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(2): 341-348. DOI: 10.12290/xhyxzz.2021-0139
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Novel Treatment Strategies for Advanced Pancreatic Ductal Adenocarcinoma

  • Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author:

    BAI Chunmei, E-mail: baichunmei1964@163.com

  • Received Date: January 31, 2021
  • Accepted Date: February 25, 2021
  • Issue Publish Date: March 29, 2022
    Graphical Abstract
    • Abstract
  • Due to the immunosuppressive microenvironment as well as the lack of medicine that targets the driver gene alterations, the prognosis of patients with pancreatic ductal adenocarcinoma(PDAC)is worse than that of other malignant tumors.At present, chemotherapy is still the main stay of treatment for most patients with advanced PDAC. In recent years, with the continuous development of anti-cancer drugs and the wide application of next-generation sequencing technology, increasing number of studies have shown that genetic alteration could guide the selection of chemotherapy regimen and molecular targeted therapy for some patients with advanced PDAC.Guidelines of the National Comprehensive Cancer Network and Chinese Society of Clinical Oncology recommend that all patients with advanced PDAC should undergo somatic and germline genetic profiling to help determining the optimal treatment strategy and to prolong patients' survival. Therapy targeting KRAS mutation, cancer vaccines and therapy of anti-tumor metabolism are still in clinical research. This article will review current status and progress of medical treatment for advanced PDAC.
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