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Volume 15 Issue 1
Jan.  2024
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LIU Yandong, DENG Qiang, ZHANG Yanjun, LI Zhongfeng, PENG Randong, GUO Tiefeng, WANG Yurong, CHEN Bo. Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 147-152. DOI: 10.12290/xhyxzz.2023-0277
Citation: LIU Yandong, DENG Qiang, ZHANG Yanjun, LI Zhongfeng, PENG Randong, GUO Tiefeng, WANG Yurong, CHEN Bo. Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 147-152. DOI: 10.12290/xhyxzz.2023-0277
shu

Research Progress on Emerging Signaling Pathways Related to Muscle Bone Symbiosis

  • 1.

    Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China

  • 2.

    Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

Funds: 

Special Project on Scientific Research for the Business Construction of National TCM Clinical Research Base of the State Administration of Traditional Chinese Medicine JDZX2015039

Gansu Province Joint Fund Project 23JRRA1534

Lanzhou Science and Technology Plan Project 2022-3-30

More Information
  • Corresponding author:

    DENG Qiang, E-mail: 2959183478@qq.com

  • Received Date: June 07, 2023
  • Accepted Date: July 17, 2023
  • Issue Publish Date: January 29, 2024
    Graphical Abstract
    • Abstract
  • Osteoporosis is a systemic metabolic bone disease characterized by decreased bone mass, damage to bone tissue microstructure, increased bone fragility, and susceptibility to fractures, while sarcopenia is a syndrome characterized by progressive reduction in overall muscle mass and functional decline. Based on the common pathophysiological mechanism and close correlation between the two, the concept of "osteosarcopenia" has gradually emerged to describe the simultaneous attenuation of muscles and bones. Signaling pathways serve as important signal transmission channels between muscles and bones, and if abnormal, they can lead to osteosarcopenia. The aim of this article, therefore, is to review the signaling pathways related to osteogenesis and myogenesis, such as Hedgehog, Hippo, mTOR, MAPK, in order to provide new ideas for targeted treatment of osteosarcopenia.
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    • References (39)
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