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Volume 14 Issue 1
Jan.  2023
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WANG Xiaodan, ZHANG Zhan, LIU Zhaohui. Analysis of Influencing Factors for High-risk Human Papillomavirus Infection[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 153-158. DOI: 10.12290/xhyxzz.2022-0193
Citation: WANG Xiaodan, ZHANG Zhan, LIU Zhaohui. Analysis of Influencing Factors for High-risk Human Papillomavirus Infection[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 153-158. DOI: 10.12290/xhyxzz.2022-0193
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Analysis of Influencing Factors for High-risk Human Papillomavirus Infection

  • Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China

Funds: 

Beijing Natural Science Foundation Youth Project 7214230

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  • Corresponding author:

    LIU Zhaohui, E-mail: liuzhaohui@ccmu.edu.cn

  • Received Date: April 08, 2022
  • Accepted Date: July 27, 2022
  • Available Online: January 02, 2023
  • Issue Publish Date: January 29, 2023
    Graphical Abstract
    • Abstract
  •   Objective  To investigate the relevant risk factors of high-risk human papillomavirus(HR-HPV) infection.
      Methods  From October 2020 to January 2021, the cases of positive HR-HPV test were selected as the infection group, and the cases of negative HR-HPV test were selected as the control group. Both groups of patients filled in self-designed "survey of HR-HPV infection-related factors" in order to explore the relevant risk factors.
      Results  A total of 125 patients in the infection group and 53 patients in the control group were included. Univariate analysis showed that there were statistically significant differences between the two groups in the following factors: unemployed or low socioeconomic status, vulva cleaning with lotion, high frequency of vaginal irrigation, homosexual orientation, production number, history of vaginitis, large amount of vaginal secretions, abnormal characteristics of vaginal secretion and chlamydia trachomatis infection(all P < 0.05). Logistic regression analysis showed that production number(OR=5.106, 95% CI: 1.521-17.145, P=0.008), previous history of vaginitis (OR=3.910, 95% CI: 1.167~13.099, P=0.027) and abnormal vaginal secretion (OR=758.313, 95% CI: 58.151~9888.714, P < 0.001) were risk factors for HR-HPV infection. In addition, the habit of using lotion to clean the vulva or vagina(OR=2.004), homosexual orientation (OR=13.972), and chlamydia trachomatis infection (OR=15.058) all showed a strong association with HR-HPV, but due to the small number of samples in the control group, no conclusions with statistical significance were drawn.
      Conclusions  HR-HPV papillomavirus infection is associated with a variety of factors. Production number, history of vaginitis and abnormal characteristics of vaginal secretion are risk factors for HR-HPV infection. It is therefore recommended to pay attention to the characteristics of vaginal secretions, and timely seek medical treatment if there is any abnormality. If possible, cervical HR-HPV screening should be added to the vaginal microecological examination. If there are reproductive tract inflammatory diseases, it should be treated in time, so as to prevent HR-HPV infection from many aspects and reduce the risk of continuing infection of HR-HPV.
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    • References (20)
  • [1]
    Zhang J, Cheng K, Wang Z. Prevalence and distribution of human papillomavirus genotypes in cervical intraepithelial neoplasia in China: a meta-analysis[J]. Arch GynecolObstet, 2020, 302: 1329-1337.
    [2]
    Cruz-Gregorio A, Aranda-Rivera AK, Pedraza-Chaverri J. Human Papillomavirus-related Cancers and Mitochondria[J]. Virus Res, 2020, 286: 198016. DOI: 10.1016/j.virusres.2020.198016
    [3]
    Norenhag J, Du J, Olovsson M, et al. The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis[J]. BJOG, 2020, 127: 171-180. DOI: 10.1111/1471-0528.15854
    [4]
    Xie L, Li Q, Dong X, et al. Investigation of the association between ten pathogens causing sexually transmitted diseases and high-risk human papilloma virus infection in Shanghai[J]. Mol Clin Oncol, 2021, 15: 132. DOI: 10.3892/mco.2021.2294
    [5]
    赵敬, 杨金豪, 张文帆, 等. 2009—2020年中国女性生殖道支原体、衣原体和人乳头瘤病毒感染与宫颈癌发生相关性的Meta分析[J]. 天津医科大学学报, 2021, 27: 396-400. https://www.cnki.com.cn/Article/CJFDTOTAL-TJYK202104019.htm
    [6]
    Tamarelle J, Thiébaut ACM, de Barbeyrac B, et al. The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: a systematic review and meta-analysis[J]. Clin Microbiol Infect, 2019, 25: 35-47. DOI: 10.1016/j.cmi.2018.04.019
    [7]
    秦丽欣, 封露露, 刘晓旭, 等. 石家庄地区部分女性高危型人乳头瘤病毒感染情况和相关危险因素分析[J]. 中国妇幼保健, 2021, 16: 3771-3774. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.16.036
    [8]
    廖琪. 2368例女性健康体检者HPV感染相关因素分析[J]. 中国性科学, 2017, 26: 54-56. https://www.cnki.com.cn/Article/CJFDTOTAL-XKXZ201702018.htm
    [9]
    魏丽惠. HPV感染现状及在宫颈癌和癌前病变筛查中的意义[J]. 实用妇产科杂志, 2017, 2: 81-83. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ201702002.htm
    [10]
    陈春林. 中国宫颈癌临床诊疗与大数据[J]. 中国实用妇科与产科杂志, 2018, 34: 25-29. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGSF201801008.htm
    [11]
    柳铮男, 谢静燕. 阴道微生物与子宫颈HPV感染及子宫颈病变的关系[J]. 实用妇产科杂志, 2022, 1: 33-36. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202201011.htm
    [12]
    侯月敏, 安瑞芳. 阴道内环境与HPV感染[J]. 实用妇产科杂志, 2021, 12: 887-889. https://www.cnki.com.cn/Article/CJFDTOTAL-SFCZ202112003.htm
    [13]
    叶雨蓝. 高危型人乳头瘤病毒阳性宫颈鳞状上皮内病变患者的高危型人乳头瘤病毒分型及阴道微生态特点[J]. 中国妇幼保健, 2022, 5: 809-812. https://www.cnki.com.cn/Article/CJFDTOTAL-ZFYB202205010.htm
    [14]
    黄晓澜, 王冬冬, 杨清. 阴道炎症与宫颈癌发生的相关性研究进展[J]. 中国微生态学杂志, 2019, 31: 485-489. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWS201904027.htm
    [15]
    Mosmann JP, Zayas S, Kiguen AX, et al. Human papillomavirus and Chlamydia trachomatis in oral and genital mucosa of women with normal and abnormal cervical cytology[J]. BMC Infect Dis, 2021, 21: 422.
    [16]
    Adebamowo SN, Ma B, Zella D, et al. Mycoplasma hominis and Mycoplasma genitalium in the Vaginal Microbiota and Persistent High-Risk Human Papillomavirus Infection[J]. Front Public Health, 2017, 5: 140.
    [17]
    Naldini G, Grisci C, Chiavarini M, et al. Association between human papillomavirus and chlamydia trachomatis infection risk in women: a systematic review and meta-analysis[J]. Int J Public Health, 2019, 64: 943-955.
    [18]
    Koster S, Gurumurthy RK, Kumar N, et al. Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming[J]. Nat Commun, 2022, 13: 1030.
    [19]
    郭凤, 黄伟, 王佩红, 等. 阴道微生态与HPV感染及宫颈病变的关系探讨[J]. 临床医学研究与实践, 2022, 9: 17-20. https://www.cnki.com.cn/Article/CJFDTOTAL-YLYS202209006.htm
    [20]
    罗燕艳, 罗小婉, 符丽华, 等. 宫颈高危型HPV感染后的转归与阴道微生态的相关性分析[J]. 中国微生态学杂志, 2022, 5: 585-589. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWS202205018.htm
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