Pulmonary Epithelioid Hemangioendothelioma with PlGF Expression: Report of a Case

 

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Abstract

Pulmonary epithelioid hemangioendothelioma (PEH) is a relatively uncommon neoplasm of vascular origin with a low or intermediate grade of malignancy. We present a case of a 28-year-old female with multiple pulmonary nodules which were diagnosed as PEH by video-assisted thoracoscopic surgery (VATS) biopsy. In addition, we performed an immunohistochemical analysis for placenta growth factor (PlGF) and a strong positivity for PlGF observed, suggesting that the PlGF may play some role in the tumorigenesis of PEH.

References

• 1 Dail D H, Liebow A A. Intravascular bronchioalveolar tumor.  Am J Clin Pathol. 1975;  78 6a-7a
  PubMedSearch in Google Scholar
• 2 He M, Das K, Blacksin M, Benevenia J, Hameed M. A translocation involving the placental growth factor gene is identified in an epithelioid hemangioendothelioma.  Cancer Genet Cytogenet. 2006;  168 150-154
  CrossrefPubMedSearch in Google Scholar
• 3 Cronin P, Arenberg D. Pulmonary epithelioid hemangioendothelioma: an unusual case and a review of the literature.  Chest. 2004;  125 789-793
  CrossrefPubMedSearch in Google Scholar
• 4 Bagan P, Hassan M, Le Pimpec-Barthes F et al. Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature.  Ann Thorac Surg. 2006;  82 2010-2013
  CrossrefPubMedSearch in Google Scholar
• 5 Amin R M, Hiroshima K, Kokubo T et al. Risk factors and independent predictors of survival in patients with pulmonary epithelioid haemangioendothelioma. Review of the literature and a case report.  Respirology. 2006;  11 818-825
  CrossrefPubMedSearch in Google Scholar
• 6 Travis W D, Tazelaar H D, Miettine M eds.. Epithelioid haemangioendothelioma/angiosarcoma. World Health Organization classification of tumors, pathology and genetics: tumors of the lung, pleura, thymus and heart.. Lyon: IARC Press; 2004: 97-98
  Search in Google Scholar
• 7 Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?.  Nat Rev Cancer. 2008;  8 942-956
  CrossrefPubMedSearch in Google Scholar
• 8 Belmont L, Zemoura L, Couderc L J. Pulmonary epithelioid haemangioendothelioma and bevacizumab.  J Thorac Oncol. 2008;  3 557-558
  CrossrefPubMedSearch in Google Scholar

Dr. Tomohiro Haruki

General Thoracic Surgery
Tottori University Hospital

36-1 Nishi-machi

683-8504 Yonago

Japan

Phone: +81 8 59 38 67 37

Fax: +81 8 59 38 67 30

Email: tharuki@med.tottori-u.ac.jp