Email Alert RSS
Volume 14 Issue 2
Mar.  2023
Turn off MathJax
Article Contents
Abstract
References
WU Guobing, CHENG Xiaolong, YU Xiao, ZHANG Aibin, LIU Min, CHEN Zhaofeng. Research Progress on the Relationship Between Helicobacter Pylori Associated Chronic Atrophic Gastritis and Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 339-345. DOI: 10.12290/xhyxzz.2022-0374
Citation: WU Guobing, CHENG Xiaolong, YU Xiao, ZHANG Aibin, LIU Min, CHEN Zhaofeng. Research Progress on the Relationship Between Helicobacter Pylori Associated Chronic Atrophic Gastritis and Gastric Cancer[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(2): 339-345. DOI: 10.12290/xhyxzz.2022-0374
shu

Research Progress on the Relationship Between Helicobacter Pylori Associated Chronic Atrophic Gastritis and Gastric Cancer

  • 1.

    The First Clinical Medical School, Lanzhou University, Lanzhou 730000, China

  • 2.

    Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou 730000, China

  • 3.

    Key Laboratory of Gastrointestinal Diseases of Gansu Province, the First Hospital of Lanzhou University, Lanzhou 730000, China

Funds: 

National Natural Science Foundation of China 81960430

Natural Science Foundation of Gansu Province 21JR1RA073

More Information
  • Corresponding author:

    CHEN Zhaofeng, E-mail: zhfchen@lzu.edu.cn

  • Received Date: May 16, 2022
  • Accepted Date: July 21, 2022
  • Available Online: July 28, 2022
  • Issue Publish Date: March 29, 2023
    Graphical Abstract
    • Abstract
  • Helicobacter pylori(HP) associated chronic atrophic gastritis (CAG) is known to be a precancerous lesion of gastric cancer, and can act on gastric carcinogenesis through a variety of factors, but the specific mechanism of action is not yet clear. In this paper, we review the research progress of the mechanism of HP associated CAG in the development of gastric cancer to provide reference for clinical medical staff.
    • FullText(HTML)
    • References (45)
  • [1]
    Correa P, Piazuelo MB. The gastric precancerous cascade[J]. J Dig Dis, 2012, 13: 2-9. DOI: 10.1111/j.1751-2980.2011.00550.x
    [2]
    Conti L, Borro M, Milani C, et al. Gastric microbiota composition in patients with corpus atrophic gastritis[J]. Dig Liver Dis, 2021, 53: 1580-1587. DOI: 10.1016/j.dld.2021.05.005
    [3]
    Yoon JH, Lee YS, Kim O, et al. NKX6.3 protects against gastric mucosal atrophy by downregulating β-amyloid production[J]. World J Gastroenterol, 2019, 25: 330-345. DOI: 10.3748/wjg.v25.i3.330
    [4]
    尹意婷, 鲁月琴, 何月敏, 等. 石斛养胃汤联合奥美拉唑肠溶胶囊对慢性萎缩性胃炎患者炎症因子及氧化应激水平的影响[J]. 新中医, 2022, 54: 108-112. DOI: 10.13457/j.cnki.jncm.2022.05.024
    [5]
    Tsukanov VV, Smirnova OV, Kasparov EV, et al. Changes in the indices of prooxidant and antioxidant systems in blood plasma in men with atrophic gastritis and gastric cancer[J]. Ter Arkh, 2018, 90: 24-27.
    [6]
    Ndegwa N, Ploner A, Andersson AF, et al. Gastric Microbiota in a Low-Helicobacter pylori Prevalence General Population and Their Associations With Gastric Lesions[J]. Clin Transl Gastroenterol, 2020, 11: e00191. DOI: 10.14309/ctg.0000000000000191
    [7]
    Liou JM, Malfertheiner P, Lee YC, et al. Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus[J]. Gut, 2020, 69: 2093-2112. DOI: 10.1136/gutjnl-2020-322368
    [8]
    Sung JJY, Coker OO, Chu E, et al. Gastric microbes associated with gastric inflammation, atrophy and intestinal metaplasia 1 year after Helicobacter pylori eradication[J]. Gut, 2020, 69: 1572-1580. DOI: 10.1136/gutjnl-2019-319826
    [9]
    Loke MF, Ng CG, Vilashni Y, et al. Understanding the dimorphic lifestyles of human gastric pathogen Helicobacter pylori using the SWATH-based proteomics approach[J]. Sci Rep, 2016, 6: 26784. DOI: 10.1038/srep26784
    [10]
    Huang JY, Goers Sweeney E, Guillemin K, et al. Multiple Acid Sensors Control Helicobacter pylori Colonization of the Stomach[J]. PLoS Pathog, 2017, 13: e1006118. DOI: 10.1371/journal.ppat.1006118
    [11]
    Pimentel-Nunes P, Barros A, Pita I, et al. Gastric microbiome profile throughout gastric carcinogenesis: beyond helicobacter[J]. Scand J Gastroenterol, 2021, 56: 708-716. DOI: 10.1080/00365521.2021.1902560
    [12]
    Zhang X, Li C, Cao W, et al. Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages[J]. Front Cell Infect Microbiol, 2021, 11: 559148. DOI: 10.3389/fcimb.2021.559148
    [13]
    Yu C, Su Z, Li Y, et al. Dysbiosis of gut microbiota is associated with gastric carcinogenesis in rats[J]. Biomed Pharmacother, 2020, 126: 110036. DOI: 10.1016/j.biopha.2020.110036
    [14]
    Zhou P, Yang T, Xu M, et al. 16S rRNA sequencing-based evaluation of the protective effects of Hua-Zhuo-Jie-Du on rats with chronic atrophic gastritis[J]. BMC Complement Med Ther, 2022, 22: 71. DOI: 10.1186/s12906-022-03542-z
    [15]
    Castaño-Rodríguez N, Goh KL, Fock KM, et al. Dysbiosis of the microbiome in gastric carcinogenesis[J]. Sci Rep, 2017, 7: 15957. DOI: 10.1038/s41598-017-16289-2
    [16]
    胡嗣基, 毛祖芬. 胃的自我保护[J]. 生物学通报, 2002, 37: 23-24. https://www.cnki.com.cn/Article/CJFDTOTAL-SWXT200204015.htm
    [17]
    Wang YK, Shen L, Yun T, et al. Histopathological classification and follow-up analysis of chronic atrophic gastritis[J]. World J Clin Cases, 2021, 9: 3838-3847. DOI: 10.12998/wjcc.v9.i16.3838
    [18]
    Caron TJ, Scott KE, Fox JG, et al. Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier[J]. World J Gastroenterol, 2015, 21: 11411-11427. DOI: 10.3748/wjg.v21.i40.11411
    [19]
    Shin SY, Kim JH, Chun J, et al. Chronic atrophic gastritis and intestinal metaplasia surrounding diffuse-type gastric cancer: Are they just bystanders in the process of carcinogenesis?[J]. PLoS One, 2019, 14: e0226427. DOI: 10.1371/journal.pone.0226427
    [20]
    Fornasarig M, Capuano A, Maiero S, et al. pCLE highlights distinctive vascular patterns in early gastric cancer and in gastric diseases with high risk of malignant complications[J]. Sci Rep, 2021, 11: 21053. DOI: 10.1038/s41598-021-00550-w
    [21]
    Capuano A, Andreuzzi E, Pivetta E, et al. The Probe Based Confocal Laser Endomicroscopy (pCLE) in Locally Advanced Gastric Cancer: A Powerful Technique for Real-Time Analysis of Vasculature[J]. Front Oncol, 2019, 9: 513. DOI: 10.3389/fonc.2019.00513
    [22]
    Miranti EH, Stolzenberg-Solomon R, Weinstein SJ, et al. Low vitamin B(12) increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer[J]. Int J Cancer, 2017, 141: 1120-1129. DOI: 10.1002/ijc.30809
    [23]
    Jiang J, Shen S, Dong N, et al. Correlation between negative expression of pepsinogen C and a series of phenotypic markers of gastric cancer in different gastric diseases[J]. Cancer Med, 2018, 7: 4068-4076. DOI: 10.1002/cam4.1615
    [24]
    Waldum H. Tumor Classification Should Be Based on Biology and Not Consensus: Re-Defining Tumors Based on Biology May Accelerate Progress, An Experience of Gastric Cancer[J]. Cancers (Basel), 2021, 13: 3159. DOI: 10.3390/cancers13133159
    [25]
    Wölffling S, Daddi AA, Imai-Matsushima A, et al. EGF and BMPs Govern Differentiation and Patterning in Human Gastric Glands[J]. Gastroenterology, 2021, 161: 623-636. DOI: 10.1053/j.gastro.2021.04.062
    [26]
    Rosania R, Varbanova M, Wex T, et al. Regulation of apoptosis is impaired in atrophic gastritis associated with gastric cancer[J]. BMC Gastroenterol, 2017, 17: 84. DOI: 10.1186/s12876-017-0640-7
    [27]
    游绍伟, 易旭, 赵琦, 等. 萎胃通调汤对大鼠慢性萎缩性胃炎癌前病变及IKKβ, Bcl-2表达的影响[J]. 中国实验方剂学杂志, 2021, 27: 55-61. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202106008.htm

    You SW, Yi X, Zhao Q, et al. Effect of Weiwei Tongtiao Decoction on Expression of IKKβ, Bcl-2 in CAG Precancerous Lesion Rats[J]. Zhongguo Shiyan Fangjixue Zazhi, 2021, 27: 55-61. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSFX202106008.htm
    [28]
    Dong CX, Deng DJ, Pan KF, et al. Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: a population-based study[J]. Int J Cancer, 2009, 124: 434-439. DOI: 10.1002/ijc.23891
    [29]
    Petersen CP, Weis VG, Nam KT, et al. Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells[J]. Gastroenterology, 2014, 146: 1727-1738. DOI: 10.1053/j.gastro.2014.02.007
    [30]
    Xiang P, Chen T, Mou Y, et al. NZ suppresses TLR4/NF-κB signalings and NLRP3 inflammasome activation in LPS-induced RAW264.7 macrophages[J]. Inflamm Res, 2015, 64: 799-808. DOI: 10.1007/s00011-015-0863-4
    [31]
    黎慧娟, 陈露, 唐畅宇, 等. TLR4/NF-κB/COX-2致炎信号通路对幽门螺杆菌相关性慢性萎缩性胃炎发生、发展的影响及机制研究[J]. 胃肠病学和肝病学杂志, 2020, 29: 773-777. DOI: 10.3969/j.issn.1006-5709.2020.07.010

    Li HJ, Chen L, Tang CY, et al. Effect and mechanism of TLR4/NF-κB/COX-2 inflammatory signaling pathway on the development and pathogenesis of Helicobacter pylori-associated chronic atrophic gastritis[J]. Weichangbingxue He Ganbingxue Zazhi, 2020, 29: 773-777. DOI: 10.3969/j.issn.1006-5709.2020.07.010
    [32]
    Cai Q, Shi P, Yuan Y, et al. Inflammation-Associated Senescence Promotes Helicobacter pylori-Induced Atrophic Gastritis[J]. Cell Mol Gastroenterol Hepatol, 2021, 11: 857-880. DOI: 10.1016/j.jcmgh.2020.10.015
    [33]
    Zhang Z, Fan B, Liu F, et al. HOX transcript antisense RNA is elevated in gastric carcinogenesis and regulated by the NF-κB pathway[J]. J Cell Biochem, 2019, 120: 10548-10555. DOI: 10.1002/jcb.28340
    [34]
    Peng Y, Zhao Q, Zhang H, et al. TIPE2, a negative regulator of TLR signaling, regulates p27 through IRF4-induced signaling[J]. Oncol Rep, 2016, 35: 2480-2486. DOI: 10.3892/or.2016.4562
    [35]
    Jeong H, Lee B, Kim KH, et al. WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury[J]. Gastroenterology, 2021, 161: 953-967. DOI: 10.1053/j.gastro.2021.05.058
    [36]
    Osaki LH, Bockerstett KA, Wong CF, et al. Interferon-γ directly induces gastric epithelial cell death and is required for progression to metaplasia[J]. J Pathol, 2019, 247: 513-523. DOI: 10.1002/path.5214
    [37]
    Rugge M, Genta RM. Staging and grading of chronic gastritis[J]. Hum Pathol, 2005, 36: 228-233. DOI: 10.1016/j.humpath.2004.12.008
    [38]
    Maric L, Castaneda D, Singh H, et al. Kimura-Takemoto Classification: A Tool to Predict Gastric Intestinal Metaplasia Progression to Advanced Gastric Neoplasia[J]. Dig Dis Sci, 2022, 67: 4092-4099. DOI: 10.1007/s10620-021-07212-x
    [39]
    Masuyama H, Yoshitake N, Sasai T, et al. Relationship between the degree of endoscopic atrophy of the gastric mucosa and carcinogenic risk[J]. Digestion, 2015, 91: 30-36. DOI: 10.1159/000368807
    [40]
    Rugge M, Sugano K, Scarpignato C, et al. Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging[J]. Helicobacter, 2019, 24: e12571. DOI: 10.1111/hel.12571
    [41]
    Salazar BE, Pérez-Cala T, Gomez-Villegas SI, et al. The OLGA-OLGIM staging and the interobserver agreement for gastritis and preneoplastic lesion screening: a cross-sectional study[J]. Virchows Arch, 2022, 480: 759-769. DOI: 10.1007/s00428-022-03286-8
    [42]
    Rugge M, Genta RM, Fassan M, et al. OLGA Gastritis Staging for the Prediction of Gastric Cancer Risk: A Long-term Follow-up Study of 7436 Patients[J]. Am J Gastroenterol, 2018, 113: 1621-1628. DOI: 10.1038/s41395-018-0353-8
    [43]
    Piazuelo MB, Bravo LE, Mera RM, et al. The Colombian Chemoprevention Trial: 20-Year Follow-Up of a Cohort of Patients With Gastric Precancerous Lesions[J]. Gastroenterology, 2021, 160: 1106-1117. DOI: 10.1053/j.gastro.2020.11.017
    [44]
    Shichijo S, Hirata Y, Niikura R, et al. Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication[J]. Gastrointest Endosc, 2016, 84: 618-624. DOI: 10.1016/j.gie.2016.03.791
    [45]
    Zhang M, Liu S, Hu Y, et al. Biopsy strategies for endoscopic screening of pre-malignant gastric lesions[J]. Sci Rep, 2019, 9: 14909. DOI: 10.1038/s41598-019-51487-0
    • Related Articles

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1216) PDF downloads (152) Cited by()
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close