Email Alert RSS
Volume 13 Issue 3
May  2022
Turn off MathJax
Article Contents
Abstract
References
Related Articles
CHEN Zihan, LI Naishi, LIAN Xiaolan. Coronavirus Disease 2019 and Thyroid Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 487-492. DOI: 10.12290/xhyxzz.2021-0791
Citation: CHEN Zihan, LI Naishi, LIAN Xiaolan. Coronavirus Disease 2019 and Thyroid Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 487-492. DOI: 10.12290/xhyxzz.2021-0791
shu

Coronavirus Disease 2019 and Thyroid Diseases

  • Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds: 

CAMS Innovation Fund for Medical Sciences 2021-1-I2M-022

More Information
  • Corresponding author:

    LI Naishi, E-mail: lns@medmail.com.cn

  • Received Date: December 14, 2021
  • Accepted Date: December 26, 2021
  • Available Online: December 29, 2021
  • Issue Publish Date: May 29, 2022
    Graphical Abstract
    • Abstract
  • Since the outbreak of coronavirus disease 2019 (COVID-19), a number of COVID-19 related thyroid disorders have been reported, including subacute thyroiditis, autoimmune thyroid disease, non-thyroidal illness syndrome and some unexplained thyroid dysfunction. This review aimed to summarize clinical characteristics of COVID-19 related thyroid disorders and to discuss some possible mechanisms.
    • FullText(HTML)
    • References (46)
  • [1]
    Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study[J]. Lancet Respir Med, 2020, 8: 475-481. DOI: 10.1016/S2213-2600(20)30079-5
    [2]
    Ge H, Wang X, Yuan X, et al. The epidemiology and clinical information about COVID-19[J]. Eur J Clin Microbiol Infect Dis, 2020, 39: 1011-1019. DOI: 10.1007/s10096-020-03874-z
    [3]
    Doustmohammadian S, Doustmohammadian A, Momeni M. Association between thyroid disorders and COVID-19: a protocol for a systematic review and meta-analysis[J]. Thyroid Res, 2021, 14: 21. DOI: 10.1186/s13044-021-00113-1
    [4]
    Pearce EN, Farwell AP, Braverman LE. Thyroiditis[J]. N Engl J Med, 2003, 348: 2646-2655. DOI: 10.1056/NEJMra021194
    [5]
    Desailloud R, Hober D. Viruses and thyroiditis: an update[J]. Virol J, 2009, 6: 5. DOI: 10.1186/1743-422X-6-5
    [6]
    Brancatella A, Ricci D, Viola N, et al. Subacute Thyroiditis After SARS-CoV-2 Infection[J]. J Clin Endocrinol Metab, 2020, 105: dgaa276. DOI: 10.1210/clinem/dgz049
    [7]
    Caron P. Thyroiditis and SARS-CoV-2 pandemic: a review[J]. Endocrine, 2021, 72: 326-331. DOI: 10.1007/s12020-021-02689-y
    [8]
    Inaba H, Aizawa T. Coronavirus Disease 2019 and the Thyroid-Progress and Perspectives[J]. Front Endocrinol(Lausanne), 2021, 12: 708333. DOI: 10.3389/fendo.2021.708333
    [9]
    Ippolito S, Dentali F, Tanda ML. SARS-CoV-2: a potential trigger for subacute thyroiditis? Insights from a case report[J]. J Endocrinol Invest, 2020, 43: 1171-1172. DOI: 10.1007/s40618-020-01312-7
    [10]
    Galeotti C, Bayry J. Autoimmune and inflammatory diseases following COVID-19[J]. Nat Rev Rheumatol, 2020, 16: 413-414. DOI: 10.1038/s41584-020-0448-7
    [11]
    Testa A, Castaldi P, Fant V, et al. Prevalence of HCV Antibodies in Autoimmune Thyroid Disease[J]. Eur Rev Med Pharmacol Sci, 2006, 10: 183-186.
    [12]
    Sultanova A, Cistjakovs M, Gravelsina S, et al. Association of Active Human Herpesvirus-6 (HHV-6) Infection With Autoimmune Thyroid Gland Diseases[J]. Clin Microbiol Infect, 2017, 23: 50 e51-50 e55.
    [13]
    Harris A, Al Mushref M. Graves' Thyrotoxicosis Following SARS-CoV-2 Infection[J]. AACE Clin Case Rep, 2021, 7: 14-16. DOI: 10.1016/j.aace.2020.12.005
    [14]
    Jiménez-Blanco S, Pla-Peris B, Marazuela M. COVID-19: a cause of recurrent Graves' hyperthyroidism? [J]. J Endocrinol Invest, 2021, 44: 387-388. DOI: 10.1007/s40618-020-01440-0
    [15]
    Mateu-Salat M, Urgell E, Chico A. SARS-CoV-2 as a trigger for autoimmune disease: report of two cases of Graves' disease after COVID-19[J]. J Endocrinol Invest, 2020, 43: 1527-1528. DOI: 10.1007/s40618-020-01366-7
    [16]
    Tee LY, Hajanto S, Rosario BH. COVID-19 Complicated by Hashimoto's Thyroiditis[J]. Singapore Med J, 2021, 62: 265. DOI: 10.11622/smedj.2020106
    [17]
    Fliers E, Boelen A. An update on non-thyroidal illness syndrome[J]. J Endocrinol Invest, 2021, 44: 1597-1607. DOI: 10.1007/s40618-020-01482-4
    [18]
    Zou R, Wu C, Zhang S, et al. Euthyroid Sick Syndrome in Patients With COVID-19[J]. Front Endocrinol (Lausanne), 2020, 11: 566439. DOI: 10.3389/fendo.2020.566439
    [19]
    Khoo B, Tan T, Clarke SA, et al. Thyroid Function Before, During, and After COVID-19[J]. J Clin Endocrinol Metab, 2021, 106: e803-e811. DOI: 10.1210/clinem/dgaa830
    [20]
    Shabana TS, Anis SG, Ibrahim DM. Association between Thyroid Dysfunction and Intensive Care Unit-Acquired Weakness: A Case-Control Study[J]. Crit Care Res Pract, 2021, 2021: 8889036.
    [21]
    Wang W, Su X, Ding Y, et al. Thyroid function abnormalities in COVID-19 patients[J]. Front Endocrinol (Lausanne), 2020, 11: 623792.
    [22]
    Chen M, Zhou W, Xu W. Thyroid function analysis in 50 patients with COVID-19: a retrospective study[J]. Thyroid, 2020, 31: 8-11.
    [23]
    Lania A, Sandri MT, Cellini M, et al. Thyrotoxicosis in patients with COVID-19: the Thyrcov study[J]. Eur J Endocrinol, 2020, 183: 381-387. DOI: 10.1530/EJE-20-0335
    [24]
    Gao W, Guo W, Guo Y, et al. Thyroid hormone concentrations in severely or critically ill patients with COVID-19[J]. J Endocrinol Invest, 2021, 44: 1031-1040. DOI: 10.1007/s40618-020-01460-w
    [25]
    Campi I, Bulgarelli I, Dubini A, et al. The spectrum of thyroid function tests during hospitalization for SARS-CoV-2 infection[J]. Eur J Endocrinol, 2021, 184: 699-709. DOI: 10.1530/EJE-20-1391
    [26]
    Güven M, Gültekin H. The prognostic impact of thyroid disorders on the clinical severity of COVID-19: results of single-centre pandemic hospital[J]. Int J Clin Pract, 2021, 75: e14129.
    [27]
    Daraei M, Hasibi M, Abdollahi H, et al. Possible role of hypothyroidism in the prognosis of COVID-19[J]. Intern Med J, 2020, 50: 1410-1412. DOI: 10.1111/imj.15000
    [28]
    Muller I, Cannavaro D, Dazzi D, et al. SARS-CoV-2-related atypical thyroiditis[J]. Lancet Diabetes Endocrinol, 2020, 8: 739-741. DOI: 10.1016/S2213-8587(20)30266-7
    [29]
    Lam SD, Bordin N, Waman VP, et al. SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals[J]. Sci Rep, 2020, 10: 16471. DOI: 10.1038/s41598-020-71936-5
    [30]
    Li MY, Li L, Zhang Y, et al. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues[J]. Infect Dis Poverty, 2020, 9: 45. DOI: 10.1186/s40249-020-00662-x
    [31]
    Rotondi M, Coperchini F, Ricci G, et al. Detection of SARS-CoV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis[J]. J Endocrinol Invest, 2021, 44: 1085-1090. DOI: 10.1007/s40618-020-01436-w
    [32]
    Moore JB, June CH. Cytokine release syndrome in severe COVID-19[J]. Science, 2020, 368: 473-474. DOI: 10.1126/science.abb8925
    [33]
    Turner AJ, Tipnis SR, Guy JL, et al. Aceh/Ace2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ace inhibitors[J]. Can J Physiol Pharmacol, 2002, 80: 346-353. DOI: 10.1139/y02-021
    [34]
    Sigrist CJ, Bridge A, Le Mercier P. A potential role for integrins in host cell entry by SARS-CoV-2[J]. Antiviral Res, 2020, 177: 104759. DOI: 10.1016/j.antiviral.2020.104759
    [35]
    Luan J, Lu Y, Gao S, et al. A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2[J]. J Infect, 2020, 81: 318-356.
    [36]
    Peng Y, Mentzer AJ, Liu G, et al. Broad and strong memory CD4+ and CD8+T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19[J]. Nat Immunol, 2020, 21: 1336-1345. DOI: 10.1038/s41590-020-0782-6
    [37]
    Coomes EA, Haghbayan H. Interleukin-6 in COVID-19: A systematic review and meta-analysis[J]. Rev Med Virol, 2020, 30: 1-9.
    [38]
    Zhang X, Tan Y, Ling Y, et al. Viral and host factors related to the clinical outcome of COVID-19[J]. Nature, 2020, 583: 437-440. DOI: 10.1038/s41586-020-2355-0
    [39]
    Lee JS, Park S, Jeong HW, et al. Immunophenotyping of COVID-19 and influenza highlights the role of type Ⅰ interferons in development of severe COVID-19[J]. Sci Immunol, 2020, 5: eabd1554. DOI: 10.1126/sciimmunol.abd1554
    [40]
    Lucas C, Wong P, Klein J, et al. Longitudinal analyses reveal immunological misfiring in severe COVID-19[J]. Nature, 2020, 584: 463-469. DOI: 10.1038/s41586-020-2588-y
    [41]
    Melo Silva Junior ML, Souza LMA, Dutra R, et al. Review on therapeutic targets for COVID-19: insights from cytokine storm[J]. Postgrad Med J, 2021, 97: 391-398. DOI: 10.1136/postgradmedj-2020-138791
    [42]
    Hariyanto TI, Kurniawan A. Thyroid disease is associated with severe coronavirus disease 2019 (COVID-19) infection[J]. Diabetes Metab Syndr, 2020, 14: 1429-1430. DOI: 10.1016/j.dsx.2020.07.044
    [43]
    Caron P. Thyroid disorders and SARS-CoV-2 infection: from pathophysiological mechanism to patient management[J]. Ann Endocrinol (Paris), 2020, 81: 507-510. DOI: 10.1016/j.ando.2020.09.001
    [44]
    Morshed SA, Latif R, Davies TF. Delineating the autoimmune mechanisms in Graves' disease[J]. Immunol Res, 2012, 54: 191-203. DOI: 10.1007/s12026-012-8312-8
    [45]
    Kawashima A, Yamazaki K, Hara T, et al. Demonstration of innate immune responses in the thyroid gland: potential to sense danger and a possible trigger for autoimmune reactions[J]. Thyroid, 2013, 23: 477-487. DOI: 10.1089/thy.2011.0480
    [46]
    Lisco G, De Tullio A, Jirillo E, et al. Thyroid and COVID-19: a review on pathophysiological, clinical and organiza-tional aspects[J]. J Endocrinol Invest, 2021, 44: 1801-1814. DOI: 10.1007/s40618-021-01554-z
    • Related Articles

  • Related Articles

    [1]ZHOU Jingya, FAN Junping, ZHANG Meng, ZHOU Jiong. Classification and Coding for Coronavirus Disease 2019 by International Classification ofDiseases: Updates and Interpretation[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(3): 328-332. DOI: 10.12290/xhyxzz.2021-0236
    [2]LI Xu, MA Xiao-chun. Severe Coronavirus Disease 2019: Is It Acute Respiratory Distress Syndrome?[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(2): 184-188. DOI: 10.3969/j.issn.1674-9081.2021.01.005
    [3]SHI Yu-xi, LI Yue, ZHU Hui-juan, ZHANG Shuo, WEI Yi-zhen, CHANG Xing, LUO Lin-zhi, JIA Xue-yan, ZHU Dan-tong, ZHANG Shu-yang. Investigation on the Core Competency of Residents during Coronavirus Disease 2019 Outbreak[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 136-140. DOI: 10.12290/xhyxzz.20200134
    [4]YU Kang, CHEN Wei, QIN Ying, SUN Wen-yan, Beijing Quality Control and Improvement Center for Clinical Nutrition Therapy. The Nutrition Management of Patients with Coronavirus Disease 2019 in the Hospital: An Expert Opinion (2020)[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 27-32. DOI: 10.12290/xhyxzz.20200212
    [5]WANG Shi-rui, CHEN Shi, ZHU Hui-juan. Evaluation and Treatment of Coronavirus Disease 2019 with Obesity[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 13-17. DOI: 10.12290/xhyxzz.20200244
    [6]SUN Xian-song, HOU Xiao-rong, LIU Xiao-ming, ZHOU Bing, CHAI Shuang, HU Ke, QIU Jie, ZHANG Fu-quan. The Experience and Inspiration on the Prevention and Control of Coronavirus Disease 2019 in the Department of Radiotherapy[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 9-12. DOI: 10.12290/xhyxzz.20200242
    [7]LI Zun-zhu, SUN Hong, CUI Wen-bo, WANG Hui, WANG Ling, LI Jie-qiong, HUANG Hai-yan, TIAN Yong-ming, CAO Lan, HU Da-ling, SUN Yan-yan, WU Xin-juan. Intra-hospital Transport of Patients with Severe Coronavirus Disease 2019:An Expert Consensus[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(6): 676-681. DOI: 10.3969/j.issn.1674-9081.2020.06.009
    [8]MA Liang-kun, DUAN Yan-ping, ZHENG Rui-min, ZENG Xue-jun, LIU Jun-tao, WEI Jing. Expert Proposal on Maternal Psychological Adjustment during the Outbreak of Coronavirus Disease 2019[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(6): 665-668. DOI: 10.3969/j.issn.1674-9081.20200031
    [9]PENG Min, SUN Xue-feng, ZHAO Jing, WANG Jing-lan, SONG Lan, WANG Meng-zhao, SHI Ju-hong, LI Tai-sheng, ZHANG Feng-chun, CAI Bai-qiang, ZHU Yuan-jue. Differential Diagnosis between Coronavirus Disease 2019 and Interstitial Pneumonia[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(6): 654-658. DOI: 10.3969/j.issn.1674-9081.2020.06.001
    [10]Fen WANG, Fan PING, An-li TONG, Wei-gang ZHAO, Xiao-lan LIAN, Wei LI. Langerhans' Cell Histocytosis with Thyroid Involvement: Report of Six Cases and Literature Review[J]. Medical Journal of Peking Union Medical College Hospital, 2015, 6(5): 333-337. DOI: 10.3969/j.issn.1674-9081.2015.05.004

  • Cited by

    Periodical cited type(1)

    1. 娄晓丽，杨丽媛，王玥，侯彦强. 新型冠状病毒肺炎与自身免疫性疾病关系的研究进展. 中华预防医学杂志. 2023(05): 785-792 .

    Other cited types(1)

Catalog

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (1685) PDF downloads (279) Cited by(2)
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return
    x Close Forever Close